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BENZYL CHLOROFORMATE (BCF)

Benzyl Chloroformate

CAS: 501-53-1

Molecular Formula: C8H7ClO2

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BENZYL CHLOROFORMATE (BCF) - Names and Identifiers

Name Benzyl Chloroformate
Synonyms Z-Cl
CBZ-Cl (Z-Cl)
Z-Cl (Cbz-Cl)
Benzyl Chlorofomate
Benzyl Chloroformate
carbobenzoxy chloride
Carboobenzoxy Chloride
benzyl chlorocarbonate
BENZYL CHLOROFORMATE (BCF)
Phenylmethyl chloroformate
Cbz-Cl (Carboobenzoxy Chloride)
Carbonochloride acid benzylester
Carbonochloridic acid, phenylmethyl ester
Benzyl Chloroformate,Carboobenzoxy Chloride
CAS 501-53-1
EINECS 207-925-0
InChI InChI=1/C8H7ClO2/c9-8(10)11-6-7-4-2-1-3-5-7/h1-5H,6H2

BENZYL CHLOROFORMATE (BCF) - Physico-chemical Properties

Molecular FormulaC8H7ClO2
Molar Mass170.59
Density1.212g/mLat 20°C
Melting Point-20 °C
Boling Point103°C20mm Hg(lit.)
Flash Point197°F
Water Solubilitydecomposes
Solubility Miscible with ether, acetone and benzene.
Vapor Presure1.39 psi ( 20 °C)
Vapor Density1 (vs air)
AppearanceSolution
ColorClear slightly yellow to slightly pink
OdorIrritating; sharp, penetrating.
Exposure LimitACGIH: TWA 1 ppmOSHA: TWA 1 ppm(5 mg/m3)NIOSH: IDLH 10 ppm; Ceiling 1 ppm(5 mg/m3)
Merck14,1801
Storage ConditionStore at +2°C to +8°C.
StabilityStable. Incompatible with water, oxidizing agents. Combustible.
SensitiveMoisture Sensitive
Refractive Indexn20/D 1.519(lit.)
Physical and Chemical PropertiesColorless oily liquid with rancid odor.
Boiling Point: 103 ℃(2666Pa)
relative density: 1.20
refractive index: 1.5160
flash point: 91 ℃
solubility: soluble in ether, acetone, benzene and other organic solvents.
UseAs an amino protectant in the synthesis of antibiotics and also as an intermediate in pesticides

BENZYL CHLOROFORMATE (BCF) - Risk and Safety

Risk CodesR45 - May cause cancer
R20 - Harmful by inhalation
R34 - Causes burns
R48/22 - Harmful danger of serious damage to health by prolonged exposure if swallowed.
R50/53 - Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment. 
R67 - Vapors may cause drowsiness and dizziness
R65 - Harmful: May cause lung damage if swallowed
R63 - Possible risk of harm to the unborn child
R48/20 -
R11 - Highly Flammable
R43 - May cause sensitization by skin contact
R37 - Irritating to the respiratory system
R23 - Toxic by inhalation
Safety DescriptionS53 - Avoid exposure - obtain special instructions before use.
S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S60 - This material and its container must be disposed of as hazardous waste.
S61 - Avoid release to the environment. Refer to special instructions / safety data sheets. 
S62 - If swallowed, do not induce vomitting; seek medical advice immediately and show this container or label.
S46 - If swallowed, seek medical advice immediately and show this container or label.
S36/37 - Wear suitable protective clothing and gloves.
UN IDsUN 2924 3/PG 2
WGK Germany3
RTECSLQ5860000
FLUKA BRAND F CODES19
TSCAYes
HS Code2915 90 70
Hazard Class8
Packing GroupI
ToxicityLD50 orally in Rabbit: 3000 mg/kg

BENZYL CHLOROFORMATE (BCF) - Nature

Open Data Verified Data

colorless oily liquid. The relative density was 1. 195. Boiling point 103 C (2.67kPa). Refractive index 5190. Flash point 91 degrees Celsius. Soluble in ether, acetone, benzene and other organic solvents. In water and ethanol will be decomposed.

Last Update：2024-01-02 23:10:35

BENZYL CHLOROFORMATE (BCF) - Preparation Method

Open Data Verified Data
  1. reaction of phosgene and benzyl alcohol benzyl alcohol and phosgene are esterified to form benzyl chloroformate, and then degassed and distilled to obtain a finished product.
  2. reaction of benzyl alcohol and trichloromethyl chloroformate
Last Update：2022-01-01 10:33:18

BENZYL CHLOROFORMATE (BCF) - Use

Open Data Verified Data

pesticide intermediates. It is used as an amino-protecting agent in the synthesis of antibiotics.

Last Update：2022-01-01 10:33:17

BENZYL CHLOROFORMATE (BCF) - Safety

Open Data Verified Data
  • This product is highly toxic. See methyl chloroformate for toxicity and protection requirements.
  • the iron drum is packed with plastic bags. According to the provisions of the storage and transportation of toxic chemicals.
Last Update：2022-01-01 10:33:18

BENZYL CHLOROFORMATE (BCF) - Reference Information

NIST chemical information Information provided by: webbook.nist.gov (external link)
EPA chemical information Information provided by: ofmpub.epa.gov (external link)
Application Benzyl chloroformate is an organic compound. In organic synthesis, it is used to introduce benzyloxycarbonyl (Cbz), which is a protection The protecting group of the amine group. At the same time, it can be used as an intermediate in organic synthesis.
Use As an amino protective agent in antibiotic synthesis, it is also used as a pesticide intermediate
Used as a semi-synthetic antibiotic intermediate
pesticide intermediate. Used as an amino protective agent in the synthesis of antibiotics.
It is used to protect amino groups in polypeptide synthesis and is also used as pesticide intermediates.
Intermediates for organic synthesis.
production method 1. It is obtained by the reaction of phosgene and benzyl alcohol. First, toluene (after drying) is used to absorb phosgene at a lower temperature, and the amount of phosgene absorbed is determined by gravimetric method. After absorbing enough phosgene, add benzyl alcohol and keep it in an ice bath for 0.5h, and then keep it at room temperature for 2h. Hydrogen chloride, excess phosgene and solvent toluene were evaporated under reduced pressure below 60 ℃, and the fraction at 101-103 ℃(2.67kPa) was collected to obtain the product with a yield of 91%-94%. 2. Benzyl alcohol and trichloromethyl chloroformate reaction method.
category corroded articles
toxicity classification poisoning
acute toxicity oral administration-rat LD50: 3000 mg/kg; Inhalation-rat LC50: 590 mg/m3/4 h
Explosive hazard characteristics Intense decomposition and explosion under the catalysis of iron salt; it is highly corrosive and irritating; thermally unstable
flammability hazard characteristics decompose carbon dioxide and toxic chloride and phosgene vapor when exposed to heat; toxic and corrosive hydrogen chloride gas when exposed to water
storage and transportation characteristics warehouse ventilation and low temperature drying; Separate storage with oxidant and alkali
fire extinguishing agent carbon dioxide, dry powder
spontaneous combustion temperature 590°C
toxic substance data information provided by: pubchem.ncbi.nlm.nih.gov (external link)
Last Update：2024-04-10 22:41:03
BENZYL CHLOROFORMATE (BCF)
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Nantong Reform Petro-Chemical CO., LTD.
Spot supply
Product Name: Benzyl Chloroformate Request for quotation
CAS: 501-53-1
Tel: +86-17551318830
Email: r@reformchem.com­
Mobile: +86-17551318830
QQ: 3785839865 Click to send a QQ messageSend QQ message
Jiangsu Pules Biotechnology Co.,Ltd.
Product Name: Benzyl Chloroformate Request for quotation
CAS: 501-53-1
Tel: 17505222756
Email: pules.cn@gmail.com
Mobile: +86-17551318830
Wechat: 17505222756
Hefei TNJ Chemical Industry Co.,Ltd.
Product Name: Benzyl Chloroformate Request for quotation
CAS: 501-53-1
Tel: 0086-551-65418684
Email: sales@tnjchem.com
　　　　 info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840 Click to send a QQ message
Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
Shanghai Yudiao Chemistry Technology Co.,Ltd
Product Name: Benzyl chloroformate Request for quotation
CAS: 501-53-1
Tel: +86 021-37285211
Email: info@yudiaochem.com
Mobile: +86 18964703211
QQ: 122752498 Click to send a QQ message
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BENZYL CHLOROFORMATE (BCF)
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